Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells

Saverio Tardito, Irene Bassanetti, Chiara Bignardi et al. · Journal of the American Chemical Society · 2011 · 317 citations

Medicine, Oncology, Pharmacology +15

In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes

Duraippandi Palanimuthu, Sridevi Vijay Shinde, Kumaravel Somasundaram et al. · Journal of Medicinal Chemistry · 2013 · 253 citations

Natural Sciences, Chemistry, Pharmacology +14

The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae

Xinjian Lin, Tsuyoshi Okuda, Alison K. Holzer et al. · Molecular Pharmacology · 2002 · 232 citations

Pharmacy, Molecular Biology, Pharmacokinetics +15

The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs

Christopher Larson, Brian Blair, Roohangiz Safaei et al. · Molecular Pharmacology · 2008 · 181 citations · Full text

Medicine, Pharmacology, Toxicology +9