Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Surya M. Nauli, Francis J. Alenghat, Ying Luo et al. · Nature Genetics · 2003 · 2K citations

Life Sciences, Cell Biology, Physiology +14

Vertebrate Smoothened functions at the primary cilium

Kevin C. Corbit, Pia Aanstad, Veena Singla et al. · Nature · 2005 · 1.5K citations

Life Sciences, Biology, Cell Biology +6

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rajat Rohatgi, Ljiljana Milenković, Matthew P. Scott · Science · 2007 · 1.5K citations

Life Sciences, Developmental Biology, Molecular Biology +17

<i>Chlamydomonas IFT</i>88 and Its Mouse Homologue, Polycystic Kidney Disease Gene <i>Tg</i>737, Are Required for Assembly of Cilia and Flagella

Gregory J. Pazour, Bethany L. Dickert, Yvonne Vucica et al. · The Journal of Cell Biology · 2000 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

<i>Chlamydomonas</i> Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in <i>Caenorhabditis elegans</i> Sensory Neurons

Douglas G. Cole, Dennis R. Diener, Amy L. Himelblau et al. · The Journal of Cell Biology · 1998 · 900 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15