Concepedia

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

Sudhir Pai Kasturi, Mohammed Ata Ur Rasheed, Colin Havenar‐Daughton, Mathew Pham, Traci Legere, Zarpheen Jinnah Sher, Yevgeniy Kovalenkov, Sanjeev Gumber, Jessica Huang, Raphaël Gottardo,

Science Immunology · 2020 · 151 citations · 56 references

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Concepts

Abstract

) cells, and persistent Env-specific plasma cells in draining lymph nodes. Overall, these results demonstrate efficacy of 3M-052 in promoting high magnitude and durability of antibody responses via robust stimulation of innate immunity and BM-resident LLPCs.

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