β-Glucocerebrosidase activity in <i>GBA</i> -linked Parkinson disease

Abstract

Residual activity of the β-glucocerebrosidase enzyme measured in blood inversely correlates with clinical severity types of <i>GBA</i> mutations in PD. β-Glucocerebrosidase activity is a quantitative endophenotype that can be monitored noninvasively and targeted therapeutically.