Theranostics · 2020 · 160 citations · 71 references
Life SciencesCell BiologyNeuroscienceAgingInflammationInnate ImmunityMitochondrial DysfunctionMitochondrial SignalingMitochondrial Stress ResponsesNeurodegenerative DiseasesNeuroinflammationNeuroprotectionAge-related Neurodegenerative MechanismsAge-related NeuroinflammationIntervertebral Disc DegenerationIntervertebral Disc HerniationIntervertebral Disc PathologyNf-κb SignalingNlrp3 InflammasomeNucleus Pulposus Degeneration
This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.
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