Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

Abstract

A FRET-based probe for mapping the fluctuation of ONOO^- in cisplatin-induced acute kidney injury was constructed. It exhibits ratiometric near infrared fluorescence and a dramatic decrease of its peak absorbance at 719 nm upon addition of ONOO^- that is converted into remarkable signal changes in fluorescence and photoacoustic images respectively.