CellBio · 2020 · 18 citations · 15 references
Life SciencesInfectious DiseasesMolecular BiologyGene ExpressionTranscriptional RegulationVirologyAntiviral ImmunityCytokine RegulationInterferon ResponsesTranscription FactorsViral PathogenesisViral PathologyKinase Inhibitor ProteinsNf-kappa B-dependent TranscriptionNuclear Factor Kappa B ActivationNuclear Factor Kappa B InhibitionNuclear Factor Kappa B ModulationNuclear Factor Kappa B SignalingTranscriptional Regulation In VirusesViral Rna Transcription
Heavy infection of the virus leads to overproduction of cytokines. The overproduction of cytokine (cytokines storms) is responsible for the critical cases and deaths of COVID-19. The nuclear factor kappa-B stimulates the expression of the genes, which is responsible for cytokines storm and RNA transcription. The COVID-19 virus can be controlled by inhibition of nuclear factor kappa-B. Nuclear factor kappa-B is controlled by inhibition of hydrogen peroxide and inhibitor kappa-B kinase enzyme.
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COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta, Daniel F. McAuley, Michael Brown et al. · The Lancet · 2020 · 10.2K citations · Full text