Concepedia

Effect of ageing on antiretroviral drug pharmacokinetics using clinical data combined with modelling and simulation

Felix Stader, Perrine Courlet, Hannah Kinvig, Manuel Battegay, Laurent A. Décosterd, Melissa A. Penny, Marco Siccardi, Catia Marzolini

British Journal of Clinical Pharmacology · 2020 · 21 citations · 31 references

DOIFull text

Open access

Abstract

Dose adjustment for antiretrovirals based on the age of male and female PLWH is a priori not necessary in the absence of severe comorbidities considering the large safety margin of the current first-line HIV treatments.

References

31

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

The Lancet · 2008 · 1.6K citations · Full text

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Sex Differences in Pharmacokinetics and Pharmacodynamics

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Future challenges for clinical care of an ageing population infected with HIV: a modelling study

Mikaëla Smit, Kees Brinkman, Suzanne E. Geerlings et al. · The Lancet Infectious Diseases · 2015 · 904 citations · Full text

A compartmental absorption and transit model for estimating oral drug absorption

Lawrence X. Yu, Gordon L. Amidon · International Journal of Pharmaceutics · 1999 · 448 citations

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Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Susanne Winiwarter, Nicholas M. Bonham, Fredrik Ax et al. · Journal of Medicinal Chemistry · 1998 · 446 citations

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