Continuous Electrochemical Synthesis of Iso‐Coumarin Derivatives from <i>o</i>‐(1‐Alkynyl) Benzoates under Metal‐ and Oxidant‐Free

Abstract

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.