An Easy‐to‐Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization

TLDR

Flow electrochemistry efficiently generates radical intermediates. An electrochemical flow microreactor was designed and manufactured to improve the efficiency of electrochemical flow reactions. The microreactor was engineered to enhance flow electrochemistry, requiring minimal electrolytes to lower costs and simplify purification, and its inline mass‑spectrometry integration enables seamless multi‑step synthesis in a single flow. The device enables facile synthesis of amidyl radicals for intramolecular hydroamination, yielding isoindolinones.

Abstract

Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.