Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy

Abstract

Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1 The authors thank Valerie Pichler and Sopie Dürauer for technical assistance and Andreas Spittler from the Flow Cytometry Core facility of the MUV for technical support.