IMPACT OF OBESITY ON FEMALE REPRODUCTIVE FUNCTION

Abstract

Standard body mass index or BMI categories fail to demonstrste corelatetion between obesity and the risk of poor reproductive function in young women. This article focuses on more specific risk factors associated with reproductive health in women apart increased BMI. The aim of this study was to evaluate the investigation of vaginal flora effectiveness as an existing screening routine technique on predicting poor reproductive outcome in obese women. For this reason we examined vaginal flora in 32 obese non-pregnant and 36 obese pregnant women. Also biochemical blood tests and examination of hormone levels was performed and compared with data obtained from 96 non-pregnant females with normal body mass index and without endocrine disorders. Unlike females with normal BMI obese patients were found to have dyslipidemia, increased level of inflammative proteins and leucocytes, activation of production of gonadotropin stimulating hormones and TSH with decreased level of prolactine, progesterone and free T4. In addition we found direct correlation between FSH, LH levels and BMI. The risk of vaginal dysbioses is not increased in obese women before and during pregnancy. Therefore further investigation and data are required in order to figure out valid route screening method in order to predict reproductive health risks in obese patients.