Enantioselective Reduction of Ketones Catalyzed by Polymer-Supported Sulfonamide Using NaBH4/Me3SiCl (or BF3⋅OEt2) as Reducing Agent

Abstract

Two remarkable reducing agents NaBH4/Me3SiCl (or BF3⋅OEt2) in combination with a new kind of chiral, polymer-supported N-sulfonamide catalyst 1 were applied to the reduction of prochiral ketones giving excellent chemical yields and enantiomeric excesses [Eq. (1)]. Supporting information for this article is available on the WWW under http://www.angewandte.com or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.