Association of vitamin B₁₂ deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan

Abstract

This study shows that vitamin B₁₂ insufficiency was frequently found in our population and may progress into B₁₂ deficiency. It is also associated with neuropathy in subjects on metformin. Further interventional studies to assess the benefit of B₁₂ treatment on painful neuropathy in patients on metformin may be warranted. B₁₂ levels may be checked in people with T2DM using metformin for >2 years.