Overriding <i>ortho</i> selectivity by template assisted <i>meta</i>-C–H activation of benzophenones

Abstract

An orthogonal selectivity for distal meta-C-H activation of benzophenone is acheived by overriding the inherent proximal ortho-selectivity through a template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C-C and C-Si bond formation.