Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · 2020 · 23 citations · 12 references
MedicineNeurologyExercise TestingPhysical ActivityPulmonary Function TestingAmyotrophic Lateral SclerosisBiomarkers Of NeurodegenerationFunctional Capacity AssessmentMotor Neuron Disease EvaluationNeurological AssessmentPhysical Activity AssessmentExploratory Clinical TrialsForced Vital Capacity ChangeFunctional Rating ScalesHeart Rate Variability IndicesHeart Rate Variability MeasurementMotor Impairment AssessmentNeurodegenerative Disease Progression MarkersPilot Study Design
OBJECTIVE: Biotelemetry measures of physical activity in this Pilot Study tracked ALS progression over time, highlighting their potential as endpoints for future clinical trials. A larger, formally powered study is required to further support activity endpoints as novel disease progression markers.
12