Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations · Full text

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

Pedro S. Coelho, Eric M. Brustad, Arvind Kannan et al. · Science · 2012 · 812 citations

Cross-coupling Reaction, Engineering, Heterocyclic +15

Catalytic Promiscuity in Biocatalysis: Using Old Enzymes to Form New Bonds and Follow New Pathways

Uwe T. Bornscheuer, Romas J. Kazlauskas · Angewandte Chemie International Edition · 2004 · 591 citations

Asymmetric Catalysis, Biosynthesis, Engineering +15

Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life

S. B. Jennifer Kan, Russell D. Lewis, Kai Chen et al. · Science · 2016 · 566 citations · Full text

A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes

Dalip Kumar, V. Buchi Reddy, Shashwat Sharad et al. · European Journal of Medicinal Chemistry · 2009 · 446 citations

Bioorganic Chemistry, Engineering, Biochemistry +10