Natural SciencesChemistryMedicinal ChemistryCatalysisReaction EngineeringCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MechanismsScaffold DiversificationAsymmetric Catalyst DesignCatalyst OptimizationChiral Catalyst DesignEnantioselective CatalysisEnantioselective Catalyst DesignEnantioselective SynthesisFluorination ProcessesFluorine Chemistry
Significance Asymmetric fluorination is an important organic transformation due to the many biologically important drugs that contain this atom. This report introduces a new catalyst system for the introduction of fluorine into the oxindole scaffold. The dimetallic catalyst 1 is shown to be a better catalyst using NFSI as a fluorine source.
1