Concepedia

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Deeba Ensan, David Smil, Carlos Zepeda‐Velázquez, Dimitrios Panagopoulos, Jong Fu Wong, R.J. Adamson, Alex N. Bullock, Taira Kiyota, Ahmed Aman, Owen G Roberts,

Journal of Medicinal Chemistry · 2020 · 28 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

), which possess high inhibitory activity against ALK2, excellent selectivity, and superior pharmacokinetic profiles.

References

25

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

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<i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 24.5K citations · Full text

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<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

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Overview of the<i>CCP</i>4 suite and current developments

Martyn Winn, Charles Ballard, Kevin Cowtan et al. · Acta Crystallographica Section D Biological Crystallography · 2011 · 12.6K citations · Full text

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Ian Davis, Andrew Leaver‐Fay, V. B. Chen et al. · Nucleic Acids Research · 2007 · 4K citations · Full text

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