<p>Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (<em>Amphimedon</em>) Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling</p>

Abstract

Our findings indicate that <i>Amphimedon</i>, total extract, petroleum ether fraction, and derived NPs are promising biosources for providing anti-HCV drug candidates, with nakinadine B and 3,4-dihydro-6-hydroxymanzamine A the most potent anti-HCV agents, possessing good oral bioavailability and penetration power.