Fast and easy conversion of <i>ortho</i> amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations

Abstract

The <italic>in silico</italic> predicted Se⋯N interaction on amidoarylselenenyl iodides has been experimentally exploited for the efficient synthesis of <italic>N</italic>-substituted benzoisoselenazol-3(2<italic>H</italic>)-ones, benzoisothiazol-3(2<italic>H</italic>)-ones and ebselen, recently reported as potent antiviral agent against Sars-Cov2.