Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial

Abstract

In this phase IIb study, phenobarbital was more effective than levetiracetam for the treatment of neonatal seizures. Higher rates of adverse effects were seen with phenobarbital treatment. Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed.