Concepedia

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

Franco Locatelli, Michael B. Jordan, Carl E. Allen, Simone Cesaro, Carmelo Rizzari, Anupama Rao, Barbara Degar, Timothy Garrington, Julián Sevilla, M C Putti,

New England Journal of Medicine · 2020 · 480 citations · 20 references

DOIFull text

Open access

Abstract

Emapalumab was an efficacious targeted therapy for patients with primary hemophagocytic lymphohistiocytosis. (Funded by NovImmune and the European Commission; NI-0501-04 and NI-0501-05 ClinicalTrials.gov numbers, NCT01818492 and NCT02069899.).

References

20

HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

Jan‐Inge Henter, AnnaCarin Horne, Maurizio Aricò et al. · Pediatric Blood & Cancer · 2006 · 5.1K citations

How I treat hemophagocytic lymphohistiocytosis

Michael B. Jordan, Carl E. Allen, Sheila Weitzman et al. · Blood · 2011 · 1.1K citations · Full text

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

Michael B. Jordan, David A. Hildeman, John W. Kappler et al. · Blood · 2004 · 703 citations · Full text

Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol

Helena Trottestam, AnnaCarin Horne, Maurizio Aricò et al. · Blood · 2011 · 662 citations · Full text

Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study

Elisabet Bergsten, AnnaCarin Horne, Maurizio Aricò et al. · Blood · 2017 · 628 citations · Full text