SARS-CoV-2 productively infects human gut enterocytes

TLDR

SARS‑CoV‑2, primarily a respiratory virus, frequently causes gastrointestinal symptoms and has been detected in anal swabs, with gut enterocytes expressing the viral entry receptor. Human intestinal organoids show that SARS‑CoV‑2 productively infects enterocytes, producing high viral loads, and provide a useful model for studying gut infection. Lamers et al., Science, p.

Abstract

Intestinal organoids as an infection model Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an influenza-like disease with a respiratory transmission route; however, patients often present with gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Moreover, the virus has been detected in anal swabs, and cells in the inner-gut lining express the receptor that SARS-CoV-2 uses to gain entry to cells. Lamers et al. used human intestinal organoids, a “mini-gut” cultured in a dish, to demonstrate that SARS-CoV-2 readily replicates in an abundant cell type in the gut lining—the enterocyte—resulting in the production of large amounts of infective virus particles in the intestine. This work demonstrates that intestinal organoids can serve as a model to understand SARS-CoV-2 biology and infectivity in the gut. Science , this issue p. 50