Concepedia

Publication | Open Access

Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma

DOIFull Paper Access

106

Citations

27

References

2020

Year

Wen‐Bin Yang, Che-Chia Hsu, Tsung‐I Hsu, Jing‐Ping Liou, Kwang‐Yu Chang, Pin‐Yuan Chen, Jr-Jiun Liu, Shung-Tai Yang, Jia‐Yi Wang, Shiu‐Hwa Yeh,
Neuro-Oncology

Abstract

Our study uncovers a previously unknown regulatory mechanism in which the HDAC6/Sp1 axis induces cell division and maintains the stem cell population to fuel tumor growth and therapeutic resistance.

References

YearCitations

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