Aging · 2020 · 29 citations · 36 references
MedicineDevelopmental BiologyAgingInfertilityReproductive PhysiologyBlastocyst DevelopmentOocyte MaturationOogenesisOvarian FunctionOvarian PhysiologyReproductive AgingAge-related Oocyte DeclineBlastocyst FormationFemale Infertility TreatmentMaternal Age EffectsOocyte AgingOocyte Maturation StageOocyte Quality DeclineTelomere Maintenance In Oocytes
treatment showed the best results for maturation rates (95.21±4.18%) of oocytes and was considered for further experiments. In conclusion, rapamycin influenced maturation rates of oocytes in a concentration-dependent manner. Our results also suggest a possible link between mTOR, telomere maintenance, and bovine blastocyst formation.
36
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Matt Kaeberlein, Ryan Powers, Kristan K. Steffen et al. · Science · 2005 · 1.3K citations
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
Pankaj Kapahi, Brian M. Zid, Tony Harper et al. · Current Biology · 2004 · 1.3K citations · Full text
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov, Janne M. Toivonen, Fiona Kerr et al. · Cell Metabolism · 2010 · 1.1K citations · Full text
Life Sciences, Biochemistry, Biology +17
Influence of TOR kinase on lifespan in C. elegans
Tibor Vellai, Krisztina Takács‐Vellai, Yue Zhang et al. · Nature · 2003 · 1.1K citations