Cell Reports · 2020 · 27 citations · 39 references
Life SciencesCell BiologyHematologyApoptosisInflammationStem Cell BiologyApoptosis RegulationHematopoietic DevelopmentHematopoietic DifferentiationHematopoietic Stem Cell BiologyHematopoietic Stem CellsStem Cell DifferentiationHematopoietic DysregulationHematopoietic HomeostasisHematopoietic Stem Cell FailureHematopoietic Stem Cell MaintenanceId Gene RegulationSinusoidal Endothelial Cell FunctionSinusoidal Endothelial FunctionStem Cell Niche Homeostasis
mice do not survive sublethal irradiation because of impaired vessel regeneration and hematopoietic failure. Thus, Id genes are required for the survival and regeneration of BM SECs during homeostasis and stress to maintain HSC development.
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