MANF improves the MPP⁺/MPTP-induced Parkinson's disease via improvement of mitochondrial function and inhibition of oxidative stress.

Abstract

OBJECTIVE: -induced model of Parkinson's disease (PD) and the potential mechanism. METHODS: . Cell viability, expression of Bax, and Bcl-2, gene expression levels of Heme oxygenase 1 (HMOX1) and Superoxide dismutase 2 (SOD2), and mitochondrial transmembrane potential were detected. RESULTS: -induced loss of mitochondrial membrane potential (P<0.01). CONCLUSION: -induced PD mice, which may be related to the improvement of mitochondrial function and inhibition of oxidative stress.