Extended Contact Lens Wear Promotes Corneal Norepinephrine Secretion and <i>Pseudomonas aeruginosa</i> Infection in Mice

Abstract

Extended CL wear elevates corneal NE content, which promotes the pathogenesis of CL-induced P. aeruginosa keratitis in mice. Targeting NE may provide a potential strategy for the treatment of CL-related corneal infection caused by P. aeruginosa.