Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging

Chonthicha Satirapod, Ning Wang, J. Macdonald, Minghan Sun, Dori C. Woods, Jonathan L. Tilly

Aging · 2020 · 17 citations · 61 references

DOIFull text

Open access

Concepts

Abstract

expression and oocyte numbers; however, both endpoints rebound to control levels after ceasing drug treatment. These findings establish a key physiological role for E2-ERα signaling in promoting OSC differentiation as a potential mechanism to maintain adequate numbers of ovarian follicles during reproductive life.

References

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