Transfer of a Human Gene Variant Associated with Exceptional Longevity Improves Cardiac Function in Obese Type 2 Diabetic Mice Through Induction of the SDF-1/CXCR4 Signalling Pathway

Abstract

In mice with type-2 diabetes, LAV-BPIFB4 gene therapy promotes an advantageous remodelling of the heart, allowing it to better withstand diabetes-induced stress. These results support the viability of transferring healthy characteristics of longevity to attenuate diabetic cardiac disease.