Concepedia

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Prahlad V. Raninga, Andy Lee, Debottam Sinha, Lan‐Feng Dong, Keshava K. Datta, Xue Lu, Priyakshi Kalita‐de Croft, Mriga Dutt, Michelle M. Hill, Normand Pouliot,

Theranostics · 2020 · 65 citations · 48 references

DOIFull text

Open access

Concepts

Abstract

: Our data provide a strong rationale for a clinical evaluation of marizomib in primary and metastatic TNBC patients.

References

48

The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes

Lisa A. Carey, Elizabeth Claire Dees, Lynda Sawyer et al. · Clinical Cancer Research · 2007 · 2.1K citations · Full text

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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

Valerie S. LeBleu, Joyce T. O’Connell, Karina N. Gonzalez Herrera et al. · Nature Cell Biology · 2014 · 1.4K citations · Full text

, , +16

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Eleni D. Lagadinou, Alexander Sach, Kevin P. Callahan et al. · Cell stem cell · 2013 · 1.4K citations · Full text

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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

Chad J. Creighton, Xiaoxian Li, Melissa D. Landis et al. · Proceedings of the National Academy of Sciences · 2009 · 1.4K citations · Full text

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Sites of distant recurrence and clinical outcomes in patients with metastatic triple‐negative breast cancer

Nancy U. Lin, Elizabeth B. Claus, Jessica Sohl et al. · Cancer · 2008 · 740 citations · Full text

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