Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma

Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth et al. · Nature · 2014 · 529 citations

Medicine, Cancer Biology, Oncology +4

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

Gabriele Sulli, Amy Rommel, Xiaojie Wang et al. · Nature · 2018 · 410 citations

Medicine, Cancer Biology, Oncology +11

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

K. Huber, E. Salah, Branka Radic-Sarikas et al. · Nature · 2014 · 390 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Sugako Oka, Mizuki Ohno, Daisuke Tsuchimoto et al. · The EMBO Journal · 2008 · 215 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16