Concepedia

Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial

Kasper Recourt, Jasper van der Aart, Gabriël E. Jacobs, Marieke de Kam, Wayne C. Drevets, Luc Van Nueten, Kawita M. S. Kanhai, Pieter Siebenga, Rob Zuiker, Paulien Ravenstijn,

Journal of Psychopharmacology · 2020 · 57 citations · 30 references

DOI

Abstract

Overall, the observed pharmacological profile of JNJ-54175446 in the dexamphetamine challenge paradigm is compatible with a potential mood-modulating effect.

References

30

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Thomas Stock, Bradley J. Bloom, Nathan Wei et al. · The Journal of Rheumatology · 2012 · 232 citations · Full text