Concepedia

Quercetin Alleviates Intestinal Oxidative Damage Induced by H<sub>2</sub>O<sub>2</sub> via Modulation of GSH: In Vitro Screening and In Vivo Evaluation in a Colitis Model of Mice

Yuanyang Dong, Qihang Hou, Jiaqi Lei, Patricia G. Wolf, Hammed Ayansola, Bingkun Zhang

ACS Omega · 2020 · 102 citations · 37 references

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Concepts

Abstract

-induced oxidative stress cell model based on the real-time cellular analysis system was an effective model to screen natural products to deal with intestinal oxidative damage and help accelerate the discovery of new drugs for inflammatory bowel disease (IBD).

References

37

Chemically induced mouse models of acute and chronic intestinal inflammation

Stefan Wirtz, Vanessa Popp, Markus Kindermann et al. · Nature Protocols · 2017 · 1.5K citations

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Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

Evan W. Miller, Bryan C. Dickinson, Christopher J. Chang · Proceedings of the National Academy of Sciences · 2010 · 693 citations · Full text

, , +15

Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells

Takuya Suzuki, Hiroshi Hara · Journal of Nutrition · 2009 · 294 citations

, , +14

Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects

Yama Abassi, Biao Xi, Wenfu Zhang et al. · Chemistry & Biology · 2009 · 256 citations · Full text

, , +13

Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression

Ki Han Kwon, Akira Murakami, Takuji Tanaka et al. · Biochemical Pharmacology · 2004 · 230 citations

, , +17