PubMed · 2018 · 20 citations · 23 references
MedicineOncologyPharmacologyCancer PharmacologyGastrointestinal OncologyMolecular OncologyAntibody ConjugatesAntibody ConjugationAntibody-drug ConjugatesPancreatic CancerTargeted Cancer TherapyTargeted TherapyAntibody-directed ProdrugsAntibody-drug Conjugate AntibodiesAntibody-drug Conjugate TherapyCancer Targeting LigandsCytotoxicity AssaysTherapeutic Efficacy AssessmentTumor Targeting Ligands
, treatment with H6-DM4 exhibited a powerful efficacy on colorectal CICs. Additionally, colorectal cancer cells resistant to platinum were effectively eliminated by H6-DM4. Taken together, our results showed 5T4-positive GI cancer cells, colorectal cancer-initiating cells, and platinum-resistant colorectal cancer cells were potently eliminated by H6-DM4, indicating H6-DM4 may be a potential candidate drug for GI cancer treatment.
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Targeting cancer stem cells: a new therapy to cure cancer patients.
Ya-Peng Hu, Liwu Fu · PubMed · 2012 · 192 citations
Medicine, Cell Biology, Oncology +12
miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1
Yulong Shang, Z Zhang, Z Liu et al. · Oncogene · 2013 · 188 citations
Immunohistological distribution of 5T4 antigen in normal and malignant tissues
PJ Southall, GM Boxer, K. D. Bagshawe et al. · British Journal of Cancer · 1990 · 185 citations · Full text