Mathematics in Engineering · 2020 · 94 citations · 29 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesEpidemiologic MethodsEpidemiologyInfectious Disease EpidemiologyDisease EpidemiologyDisease ForecastingDisease SpreadEpidemic ForecastingInfectious Disease DynamicsTransmission DynamicsEpidemic ModelsForecasting Disease DynamicsForecasting Disease OutbreaksForecasting Epidemic TrajectoriesForecasting Infectious Disease TransmissionInfectious Disease ModelsInfectious Disease Risk Modeling
There is increasing evidence that one of the most difficult problems in trying to control the ongoing COVID-19 epidemic is the presence of a large cohort of asymptomatic infectives. We develop a SIR-type model taking into account the presence of asymptomatic, or however undetected, infective, and the substantially long time these spend being infective and not isolated. We discuss how a SIR-based prediction of the epidemic course based on early data but not taking into account the presence of a large set of asymptomatic infectives would give wrong estimate of very relevant quantities such as the need of hospital beds, the time to the epidemic peak, and the number of people which are left untouched by the first wave and thus in danger in case of a second epidemic wave. In the second part of the note, we apply our model to the COVID-19 epidemics in Northern Italy. We obtain a good agreement with epidemiological data; according to the best fit of epidemiological data in terms of this model, only 10% of infectives in Italy is symptomatic.
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The Mathematics of Infectious Diseases
Herbert W. Hethcote · SIAM Review · 2000 · 6.9K citations
Presumed Asymptomatic Carrier Transmission of COVID-19
Yan Bai, Tao Wei, Fei Tian et al. · JAMA · 2020 · 4.9K citations · Full text
Veterinary Medicine, Infectious Diseases, Infectious Disease Epidemiology +10