The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)

Abstract

The cytotoxic effect of the antitumor drug aurumacryl (gold polyacrylate) against human tumor cells of various origins has been studied. It has been shown that aurumacryl exhibits significant cytotoxic activity against cells of lung carcinoma А549 (IC50 = 60 μg/mL), melanoma Mel-mо (IC50 = 80 μg/mL), and breast carcinoma MCF-7 (IC50 = 90 μg/mL), while being substantially less efficient against colon carcinoma НСТ116 cells (IC50 = 180 μg/mL).