Synthesis of CH₂-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct <i>C</i>-glycosylation

Abstract

Direct <italic>C</italic>-glycosylation of a conformationally constrained and stable C1-sp³ hybridized carbohydrate donor with a carefully designed sphingosine unit afforded the CH₂-linked analogue of antitumor-active KRN7000 and its glucose congener.