Numerical Modeling of Glucose Biosensor With pH-Based Electrochemical Field-Effect Transistor Device

Abstract

In this article, we present a new model for glucose detection using an electrochemical field-effect transistor (ElecFET) with the MATLAB software. ElecFET is a device in which the basic element is a pH-sensitive chemical field-effect transistor (pH-ChemFET) designed with an integrated platinum microelectrode around the sensitive gate dielectric capable to trigger electrochemical reactions. A number of parameters, such as polarization time (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pol</sub> ) and polarization voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sub> ), have been investigated, as well as the enzymatic unit number per volume (N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">enz</sub> ), the Michaelis constant (K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</sub> ), and the glucose concentration (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ). Each of the aforementioned parameters influences the glucose sensor response. Experimental data compared with our numerical model showed a reasonable fit.