Publication | Open Access
Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(<scp>iv</scp>) prodrugs
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Citations
43
References
2020
Year
Cisplatin ResistanceMedicineApoptosisCell DeathCancer Cell BiologyCancer BiologyHomologous Recombination ProteinsCisplatin-resistant Cancer CellsCancer CellsCancer TreatmentAnti-cancer AgentRadiation OncologyPharmacologyCell BiologyCancer ResearchTumor Biology
Platinum(<sc>iv</sc>) prodrugs targeting the DNA repair mechanism downregulate myeloid cell leukemia-1 (Mcl-1) and homologous recombination proteins (RAD51, BRCA2), thereby enhancing cytotoxicity against cisplatin-resistant cancer cells.
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