Use of local genetic ancestry to assess <i>TOMM40</i> -523′ and risk for Alzheimer disease

Abstract

Adjustment for LGA confirms that <i>TOMM40</i>-523' cannot explain the strong differential risk for LOAD between <i>APOE</i> ε4 with EUR and AF LGA. Our study does confirm previous reports that increasing allele length of the <i>TOMM40-523'</i> repeat is associated with decreased risk for LOAD in carriers of homozygous <i>APOE</i> ε3 alleles and demonstrates that this effect is occurring in those individuals with the EUR LGA <i>APOE</i> ε3 allele haplotype.