Chemical constituents from the barks of <i>Melia azedarach</i> and their PTP1B inhibitory activity

Abstract

One new long-chain ester derivative of trans-ferulic acid <b>1</b> and one natural tirucallane-type triterpenoid <b>2</b>, together with forty known compounds (<b>3-42</b>), were isolated from the barks of <i>Melia azedarach</i>. Their structures were established on the basis of spectroscopic data interpretation. Compounds <b>7</b>, <b>9</b>, <b>10</b>, <b>12</b>, <b>13</b> showed significant inhibitory activities against PTP1B with IC₅₀ values of 13.82 ± 1.29 μM, 13.29 ± 2.26 μM, 20.27 ± 0.52 μM, 24.36 ± 1.25 μM, 15.23 ± 0.6 μM, respectively.