Concepedia

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

Niklas G. Johansson, Ainoleena Turku, Keni Vidilaseris, Loïc Dreano, Ayman Khattab, Daniel Ayuso Pérez, Aaron Wilkinson, Yuezhou Zhang, Matti Tamminen, Evgeni Grazhdankin,

ACS Medicinal Chemistry Letters · 2020 · 20 citations · 24 references

DOIFull text

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Concepts

Abstract

mPPase in membranes and inhibited parasite growth.

References

24

Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening

Martin J. Smilkstein, Nongluk Sriwilaijaroen, Jane X. Kelly et al. · Antimicrobial Agents and Chemotherapy · 2004 · 1.2K citations · Full text

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The Malaria Cell Atlas: Single parasite transcriptomes across the complete <i>Plasmodium</i> life cycle

Virginia M. Howick, Andrew J. C. Russell, Tallulah Andrews et al. · Science · 2019 · 330 citations

, , +17

Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy

Tyler N. Bennett, Michelle F. Paguio, Bojana Gligorijevic et al. · Antimicrobial Agents and Chemotherapy · 2004 · 280 citations · Full text

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Integrating vector control across diseases

Nick Golding, Anne L. Wilson, Catherine L. Moyes et al. · BMC Medicine · 2015 · 178 citations · Full text

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Crystal structure of a membrane-embedded H+-translocating pyrophosphatase

Shih-Ming Lin, Jia‐Yin Tsai, Chwan‐Deng Hsiao et al. · Nature · 2012 · 164 citations

, , +14