Heliyon · 2020 · 24 citations · 19 references
PharmacyPharmaceuticsPharmacologyChemotherapyDrug DeliveryTargeted Drug DeliveryCancer Drug DeliveryChelation TherapyColorectal CancerPharmacodynamics Of Anticancer AgentsPharmacodynamics Of Anticancer DrugsPharmacokinetics Of Anticancer Drugs5-Fluorouracil TreatmentAnticancer ActivityAnticancer ChemotherapyAnticancer Drug FormulationChemotherapy DeliveryColon-specific CoatingsLocalized Drug DeliveryPharmacokinetic Parameters
in the finished formulation, indicates lower systemic exposure to the drug. X-ray radiography ensures the localized delivery of the encapsulated drug. Histopathological studies indicated no significant local toxicity compared to the uncoated formulation. Results inferred that the proposed combination has superior anticancer activity with minimum systemic and local toxicity and it opens a new avenue in the treatment of colorectal cancer.
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Christina Fitzmaurice, Christine A. Allen, Ryan M Barber et al. · JAMA Oncology · 2016 · 6.3K citations · Full text
Oxidative Stress and Antioxidant Defense
Esra Birben, Ümit Murat Şahiner, Cansın Saçkesen et al. · World Allergy Organization Journal · 2012 · 4.9K citations · Full text
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years
Fanny E. Vuik, Stella A. V. Nieuwenburg, Marc Bardou et al. · Gut · 2019 · 903 citations · Full text