Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

Jong‐Dae Lee, Tsung‐Hsien Chuang, Vanessa Redecke et al. · Proceedings of the National Academy of Sciences · 2003 · 582 citations · Full text

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

Dmitri Smirnov, Joshua Schmidt, John T. Capecchi et al. · Vaccine · 2011 · 170 citations

Vaccination, Inflammation, Mucosal Vaccination +11

Synthesis and Structure−Activity-Relationships of 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolines That Induce Interferon Production

John F. Gerster, Kyle J. Lindstrom, Richard L. Miller et al. · Journal of Medicinal Chemistry · 2005 · 116 citations

Bioorganic Chemistry, Cell Culture Systems, Immunology +16

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

Michael Chan, Tomoko Hayashi, Crystal S. Kuy et al. · Bioconjugate Chemistry · 2009 · 108 citations · Full text

Innate Immune System, Immunology, Immunologic Mechanism +16

A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily

Philip Savage, Vicki L. Horton, J. Moore et al. · British Journal of Cancer · 1996 · 107 citations · Full text

Immunodeficiencies, Immunology, Oral Interferon Inducer +2