Concepedia

Mendelian Randomization Study of Obesity and Cerebrovascular Disease

Sandro Marini, Jordi Merino, B. E. Montgomery, Rainer Malik, Martin Dichgans, José C. Florez, Jonathan Rosand, Dipender Gill, Christopher D. Anderson

Annals of Neurology · 2020 · 148 citations · 32 references

DOIFull text

Open access

Abstract

Abdominal adiposity may trigger causal pathological processes, partially independent from blood pressure and totally independent from glucose levels, that lead to cerebrovascular disease. Potential targets of these pathological processes could represent novel therapeutic opportunities for stroke. ANN NEUROL 2020;87:516-524.

References

32

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.2K citations · Full text

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.2K citations · Full text

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 8.8K citations · Full text

, , +13

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess, Adam S. Butterworth, Simon G. Thompson · Genetic Epidemiology · 2013 · 6.2K citations · Full text

, , +28

Prevalence of Obesity Among Adults and Youth: United States, 2015-2016.

Craig M. Hales, Margaret D. Carroll, Cheryl D. Fryar et al. · PubMed · 2017 · 3.9K citations

, , +14