Molecular Therapy — Methods & Clinical Development · 2020 · 32 citations · 29 references
Life SciencesCell BiologyImmunologyCell TherapyRegenerative MedicineStem Cell BiologyCell-based TherapiesNeural Stem Cell BiologyNeural Stem CellsCd8 Positive T CellsHla ImmunogenicityImmune Cell Cytokine ProductionInduced Pluripotent Stem Cell ImmunogenicityInduced Pluripotent Stem CellsMixed Lymphocyte ReactionStem Cell ImmunomodulationT Cell Cytokine Production
T cells or induce cytokine production. We show that this was not a result of any immunosuppressive features of iPSC-NCSCs, but rather more consistent with their non-immunogenic molecular phenotype. These results are encouraging for the potential future use of iPSC-NCSCs as a cellular therapy.
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Ichiro Sekiya, Benjamin L. Larson, Jason R. Smith et al. · Stem Cells · 2002 · 962 citations · Full text