Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and IRS1-AKT-GLUT2 signaling pathways

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Carles Cantó, Zachary Gerhart‐Hines, Jérôme N. Feige et al. · Nature · 2009 · 3.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Atomic structure of the entire mammalian mitochondrial complex I

Karol Fiedorczuk, James A. Letts, Gianluca Degliesposti et al. · Nature · 2016 · 555 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

Daisuke Kukidome, Takeshi Nishikawa, Kazuhiro Sonoda et al. · Diabetes · 2006 · 493 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Hydrogen sulfide (H ₂ S) metabolism in mitochondria and its regulatory role in energy production

Ming Fu, Weihua Zhang, Lingyun Wu et al. · Proceedings of the National Academy of Sciences · 2012 · 468 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

Seiji Nakamura, Toshinari Takamura, Naoto Nagata et al. · Journal of Biological Chemistry · 2009 · 429 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17