Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: Results from a mechanistic PK-PD mechanostat model of bone remodeling

Bone “mass” and the “mechanostat”: A proposal

Harold M. Frost · The Anatomical Record · 1987 · 2.1K citations

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Xiaofeng Li, Heeseog Kang, Wenzhong Liu et al. · Journal of Biological Chemistry · 2005 · 1.3K citations · Full text

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Alexander G. Robling, Paul Niziolek, Lee Ann Baldridge et al. · Journal of Biological Chemistry · 2007 · 1.3K citations · Full text

Sclerostin, Engineering, Ulnar Cortex +21

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

D. G. Winkler · The EMBO Journal · 2003 · 1.1K citations · Full text

Regenerative Medicine, Mechanobiology, Sclerostin +14

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

Rutger L. van Bezooijen, Bernard A.J. Roelen, Annemieke Visser et al. · The Journal of Experimental Medicine · 2004 · 876 citations · Full text

Sclerostin, Bone Surface, Immunology +21